Therapeutic Window of Lamotrigine for Mood Disorders: A Naturalistic Retrospective Study
نویسندگان
چکیده
منابع مشابه
Therapeutic window of lamotrigine for mood disorders: a naturalistic retrospective study.
INTRODUCTION Lamotrigine is widely used for mood disorders including bipolar disorder and major depression, but its therapeutic levels have yet to be determined. This study was conducted to investigate the hypothesis that lamotrigine may have a therapeutic window for mood disorders. METHODS 25 patients with mood disorders received lamotrigine for more than one year during which time plasma la...
متن کاملLamotrigine in adolescent mood disorders: a retrospective chart review.
INTRODUCTION Treatment nonresponse in adolescent mood disorders is a major public health problem, as mood disorders in youth are associated with significant mortality by suicide, protracted course of illness, and recurrence into adulthood. Three studies with small sample sizes exist for lamotrigine in youth mood disorders. However, the risk of serious rash has limited its use in youth mood diso...
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BACKGROUND Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies rarely exceed 2-year follow up. We report a naturalistic 5-year follow up of five patients who rec...
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Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in putative novel treatments for mood disorders. These include: (1) glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC), (2) the purinergic ...
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attempts have been made to study the thermodynamic behavior of 1,3 butadiene purification columns with the aim of retrofitting those columns to more energy efficient separation schemes. 1,3 butadiene is purified in two columns in series through being separated from methyl acetylene and 1,2 butadiene in the first and second column respectively. comparisons have been made among different therm...
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ژورنال
عنوان ژورنال: Pharmacopsychiatry
سال: 2014
ISSN: 0176-3679,1439-0795
DOI: 10.1055/s-0034-1375618